Globally, the prevalence of anti-tuberculosis drug resistance has been increasing. This study sought to identify trends in multidrug-resistant tuberculosis (MDR-TB) among foreign-born persons in Alberta, a major immigrant-receiving province of Canada. Of the 2,234 foreign-born culture-positive TB cases in Alberta in 1982–2011, 27 had MDR-TB. Overall, MDR was associated with age <65 years, TB relapse/retreatment, and diagnosis and arrival in the last decade (2002–2011). Recent trends in the prevalence and clinical characteristics of foreign-born MDR-TB cases have important implications for TB case management in Canada. Early diagnosis of MDR-TB, using genotypic drug susceptibility testing, is suggested in foreign-born TB cases at increased risk of being MDR.