In response to recent refugee crises around the world, scholars have called for research on resilience among war-affected children and youth as an important area of focus that offers culturally and contextually relevant implications for effective support services. While empirical research on the resilience of refugee youth has been gradually increasing, the current scholarship still lacks social, cultural, and contextual sensitivity. As such, this dissertation research, which consists of three conceptually linked manuscripts, represents a purposeful attempt to address this gap by exploring the resilience of refugee youth in a postmigration Canadian context, with contributions to research, policy, and practice. Refugee youth were recruited from Calgary, Vancouver, Montreal and Toronto. Manuscript 1 centres on the definition of refugee youth resilience as it relates to postmigration resettlement and explores the theoretical connections between resilience and positive adaptation. This manuscript proposes a culturally and contextually relevant conceptualization of resilience from the bioecological lens, integrating the three intertwined developmental, acculturative, and psychological perspectives. Manuscript 2 focuses on a critical and extensive review of the extant literature on refugee children and youth. It synthesizes empirical evidence from scholarship on young refugees’ resilience and presents a host of biological, psychological, social and cultural determinants of resilience, which interact with one another across multiple levels of social and ecological contexts to determine adaptive responds to stressful experiences. Finally, Manuscript 3 reflects qualitative research on pathways leading to positive adaptation to a Canadian postmigration context to provide knowledge about the pathways leading to resilience among refugee youth. It outlines a classic grounded theory study that generated a substantive theory conceptually explaining the underlying process of positive adaptation from the perspectives of 15 Canadian refugee youth. Together, findings from this dissertation research spur integration of knowledge and strategies to inform practice and policies to mitigate risk and promote resilience in multiple systems that shape refugee youth adaptation over the resettlement course.